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FILE - The injectable drug Ozempic in Houston on July 1, 2023. (AP Photo/David J. Phillip, File)

What to know about how GLP-1 medications might fight addiction

6:47 PM on Wednesday, March 4

A new study finds that popular GLP-1 drugs used to treat diabetes and obesity show new promise in fighting multiple substance use disorders

Homeland Security Secretary Kristi Noem testifies during a House Committee on the Judiciary oversight hearing of the Department of Homeland Security on Capitol Hill, Wednesday, March 4, 2026, in Washington. (AP Photo/Mariam Zuhaib)

Noem defends Homeland Security Department in post-shooting appearances before Congress

6:19 PM on Wednesday, March 4

Homeland Security Secretary Kristi Noem wrapped up two days of scrutiny in Congress, appearing for the first time in front of lawmakers since the shooting deaths of two protesters in Minneapolis at the hands of immigration enforcement officers

The Brady Bunch House, the two-story single-family home that served as the main setting for the television series "The Brady Bunch" in the Studio City neighborhood of Los Angeles, Wednesday, March 4, 2026, is now designated as a Los Angeles Historic-Cultural Monument. (AP Photo/Damian Dovarganes)

'Brady Bunch' house, used in exterior shots for the popular sitcom, gets LA landmark status

6:16 PM on Wednesday, March 4

The LA city council has voted unanimously to designate the the so-called “Brady Bunch” house in the San Fernando Valley as a historic-cultural monument

FILE - Cuba's President Raul Castro listens to the Cuban and Venezuelan national anthems during his welcome ceremony at the Miraflores presidential palace, March 17, 2015, in Caracas, Venezuela. (AP Photo/Ariana Cubillos, File)

Florida revives a long-dormant probe into Raul Castro over 1996 shootdown of exile group's plane

6:03 PM on Wednesday, March 4

Florida’s attorney general says Florida has reopened a criminal investigation into former Cuban leader Raul Castro’s role in the 1996 shootdown of exile planes

This graphic includes small multiple symbol maps showing the vote share for Republican U.S. Senate candidates John Cornyn and Ken Paxton as well as for Democratic U.S. Senate candidates James Talarico and Jasmine Crockett, helping to show where these candidates drew support from in the March 3 primary. (AP Digital Embed)

The first midterm primaries of 2026, by the numbers

5:49 PM on Wednesday, March 4

The first primaries of the year weren’t short on drama

Senate Republicans vote down legislation to halt war against Iran in early show of support for Trump’s campaign

5:24 PM on Wednesday, March 4

Senate Republicans vote down legislation to halt war against Iran in early show of support for Trump’s campaign

Containers are stored in a cargo terminal in Frankfurt, Germany, Monday, Feb. 23, 2026. (AP Photo/Michael Probst)

Judge rules companies are entitled to refunds for Trump tariffs overturned by the Supreme Court

5:15 PM on Wednesday, March 4

In a defeat for the Trump administration, a federal judge in New York ruled Wednesday that companies that paid tariffs struck down last month by Supreme Court are due refunds

Judge rules companies are entitled to refunds for Trump tariffs they paid but that were overturned by the Supreme Court

5:04 PM on Wednesday, March 4

Judge rules companies are entitled to refunds for Trump tariffs they paid but that were overturned by the Supreme Court

Virginia’s top court allows a voter referendum on Democrat-led redistricting that aims to flip 4 US House seats

5:03 PM on Wednesday, March 4

Virginia’s top court allows a voter referendum on Democrat-led redistricting that aims to flip 4 US House seats

Lou Holtz, the college football staple who coached Notre Dame to the 1988 national title and captivated fans, dies at 89

5:03 PM on Wednesday, March 4

Lou Holtz, the college football staple who coached Notre Dame to the 1988 national title and captivated fans, dies at 89

How major US stock indexes fared Wednesday, 3/4/2026

4:22 PM on Wednesday, March 4

The U.S. stock market rebounded after oil prices stopped spiking and reports gave encouraging updates on the economy

The top photos of the day by AP's photojournalists

3:42 PM on Wednesday, March 4

US issues first commercial construction permit for a nuclear reactor in 8 years to a Gates-backed Wyoming project

3:29 PM on Wednesday, March 4

US issues first commercial construction permit for a nuclear reactor in 8 years to a Gates-backed Wyoming project

FILE - Kevin Warsh, visiting fellow at the Hoover Institution, speaks at the Council on Foreign Relations in a panel discussion on "Central Banking in an Age of Improvisation," Nov. 28, 2011 in New York. (AP Photo/Mark Lennihan, File)

White House formally nominates Warsh to be Federal Reserve chair

3:06 PM on Wednesday, March 4

The Trump administration has formally nominated Kevin Warsh, a former top Federal Reserve official, to be next Fed chair when Jerome Powell’s term ends in two months

FILE - The headquarters of the Internal Revenue Service is in Washington, August 10, 2024. (AP Photo/Ted Shaffrey, File)

IRS leader Bisignano declines to answer questions over unlawful taxpayer data disclosures to ICE

2:03 PM on Wednesday, March 4

IRS chief Frank Bisignano has largely declined to answer questions from lawmakers about unlawful releases of taxpayer data to immigration agents

The sculpted bust inside the Basilica of Saint Agnes Outside the Walls, in Rome, Wednesday, March 4, 2026, which, in light of new studies by Italian researcher Valentina Salerno, may be reattributed to Michelangelo Buonarroti. (AP Photo/Gregorio Borgia)

Claims of 'rediscovered' Michelangelos unsettle Renaissance experts

1:08 PM on Wednesday, March 4

An independent researcher has asserted that a marble bust of Christ in a Roman church is by Michelangelo

FILE - Dilrukshan Kumara looks at the ocean as he stands by the remains of his family's home in Iranawila, Sri Lanka, June 15, 2023. (AP Photo/Eranga Jayawardena, File)

The sea is higher than we thought and millions more are at risk, study finds

11:01 AM on Wednesday, March 4

A new study in the journal Nature says most sea level rise research may have underestimated coastal water heights by an average of 1 foot or about 30 centimeters

Financial information is displayed on the floor at the New York Stock Exchange in New York, Wednesday, March 4, 2026. (AP Photo/Seth Wenig)

US stocks rebound after strong economic updates and as oil prices stop spiking

9:49 PM on Tuesday, March 3

The U.S. stock market rebounded after oil prices stopped spiking and reports gave encouraging updates on the economy

Texas state Rep. James Talarico, D-Austin, a Democratic candidate for the U.S. Senate, speaks at a primary election watch party Tuesday, March 3, 2026, in Austin, Texas. (AP Photo/Eric Gay)

Talarico wins Texas Senate Democratic nomination while Cornyn and Paxton head to Republican runoff

12:01 AM on Tuesday, March 3

State Rep. James Talarico topped Congresswoman Jasmine Crockett in Texas' closely watched Democratic Senate primary

Paula Wood holds a sign protesting Missouri’s congressional redistricting effort while sitting beside her husband, Tim Wood, during a rally on Jan. 21, 2026, at the state Capitol in Jefferson City, Mo. (AP Photo/David A. Lieb)

US House campaigns are underway. Yet a redistricting battle triggered by Trump rages in some states

11:43 AM on Friday, February 20

A partisan battle to redraw U.S. House districts is raging in some states, even though campaigning is underway

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