Ambience Healthcare Becomes First Ambient AI Platform to Launch Inpatient CDI at the Point of Care, Built on OpenAI

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SAN FRANCISCO--(BUSINESS WIRE)--Sep 30, 2025--

Ambience Healthcare today announced the launch of the industry’s first Inpatient ICD-10 CDI Assistant, which helps hospitalists document precise, compliant diagnoses during the patient encounter, ensuring clinical complexity is accurately captured and audit-ready from the start.

Built on top of OpenAI GPT-5’s advanced reasoning capabilities with Ambience’s proprietary models, the platform addresses one of hospital medicine’s most persistent challenges: bridging the gap between clinical complexity and clinical documentation integrity.

Clinical Documentation Integrity (CDI) refers to the discipline of ensuring that the medical record accurately and completely reflects a patient’s clinical picture and care. In many hospitals today, dedicated CDI and coding professionals work alongside clinicians to improve the accuracy and completeness of documentation—often retrospectively, long after care has been rendered. Accurate, coding-aware documentation is essential not only for appropriate reimbursement, but also for how health systems risk-stratify populations, manage care, and capture quality and patient safety outcomes.

“The inpatient setting is where the most complex patients are treated and where documentation is most burdensome,” said Mike Ng, President and Chairman of Ambience Healthcare. “By addressing CDI upstream, at the point of care, we’re helping hospitals create records that are accurate, audit-ready, and reflective of true clinical complexity.”

AI Technology for Inpatient Complexity

Clinicians in the inpatient setting face relentless documentation demands across admission, rounding, handoffs, and discharge. Yet the burden of capturing diagnostic complexity consistently falls back on the clinician—while coding, CDI, and quality leaders are left trying to determine accuracy after the fact. This leads to increased audit risk and reimbursement delays.

Ambience’s new inpatient CDI solution eliminates this friction by equipping hospitalists with real-time support for diagnostic specificity, POA designations, and complication tracking, embedded seamlessly in their existing Epic workflows.

“This technology represents a fundamental shift in how clinical documentation supports both care delivery and compliance,” said Ray Chen, MD, Head of Clinical AI at Ambience Healthcare. “By enabling accurate coding and diagnostic specificity at the point of care, we reduce administrative burden and ensure that the clinical story is faithfully captured — which translates into more informed treatment decisions, better continuity of care, and ultimately improved outcomes for patients.”

Built for Clinical Specificity

Ambience’s inpatient CDI platform represents a new category of clinical AI designed specifically for hospital medicine. Unlike general-purpose models retrofitted for healthcare, Ambience’s inpatient tools were engineered for compliance, auditability, and clinical nuance. Key features include:

• Explainable Audit Trail: Every suggested diagnosis includes clinical rationale and supporting documentation references
  
  
• Compliance-First Design: Built-in guardrails ensure all suggestions meet CMS guidelines and audit requirements
  
  
• Workflow-Native Integration: Seamlessly embedded in existing EHR workflows without disrupting clinician routines

By enabling accurate, progressive specificity in ICD-10 coding from the outset, Ambience supports better care coordination, more accurate risk stratification, and stronger alignment between clinical documentation and financial integrity.

Clinicians report that the system prompts them to document with more precision, transforming how diagnostic information is recorded and applied across the entire continuum of care.

About Ambience Healthcare

Ambience Healthcare is the leading AI platform for documentation, coding, and clinical workflow, built to reduce administrative burden and protect revenue integrity at the point of care. Trusted by top health systems across North America, Ambience’s platform is live across outpatient, emergency, and inpatient settings, supporting more than 100 specialties with real-time, coding-aware documentation. The platform integrates directly with Epic, Oracle Cerner, athenahealth, and other major EHRs. Founded in 2020 by Mike Ng and Nikhil Buduma, Ambience is headquartered in San Francisco and backed by Oak HC/FT, Andreessen Horowitz (a16z), OpenAI Startup Fund, Kleiner Perkins, and other leading investors.

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CONTACT: Media ContactKarina Stabile

Aria Marketing for Ambience Healthcare

[email protected]

516-317-5835

KEYWORD: CALIFORNIA UNITED STATES NORTH AMERICA

INDUSTRY KEYWORD: TECHNOLOGY HOSPITALS HEALTH TECHNOLOGY SOFTWARE PRACTICE MANAGEMENT MANAGED CARE HEALTH GENERAL HEALTH ARTIFICIAL INTELLIGENCE

SOURCE: Ambience Healthcare

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PUB: 09/30/2025 09:30 AM/DISC: 09/30/2025 09:30 AM

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